Americans face at least 2 weeks of uncertainty as scientists work to answer 3 key questions about the new Omicron variant

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Americans face at least two weeks of uncertainty before major questions may get answered about the Omicron variant of the coronavirus.

Health experts urge the public to be cautious and patient as scientists try to find out if Omicron – deemed a “variant of concern” by the World Health Organization – is more transmissible and dangerous than other forms of the novel coronavirus and whether existing vaccines work against it.

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Omicron variant cases have been detected in numerous countries, including Canada. No cases have been found in the United States, but many experts says it’s inevitable.

The overall global risk related to the newly discovered B.1.1.529 strain of the coronavirus “is assessed as very high,” the WHO said in a technical brief Monday.

Warnings about the renewed threat from the Omicron variant come as Americans have become weary of nearly two years of precautions and are returning from a Thanksgiving break that saw air travel at close to pre-pandemic levels.

Experts are now racing to determine the answers to these three critical questions:

• Do Omicron’s mutations make it more transmissible?

• Is it more severe or dangerous or deadly than other variants?

• Is it more resistant to vaccines?

It could be weeks before we have the answers.

At least 44 countries have imposed travel restrictions from several African countries following the discovery of the variant.

In the meantime, US travel restrictions on flights from South Africa, Botswana, Zimbabwe, Namibia, Lesotho, Eswatini, Mozambique and Malawi went into effect overnight. The Omicron variant was first identified by scientists in South Africa and has been detected in multiple countries.

With much about Omicron still unknown, officials say vaccinations and boosters remain the best protection available.

Right now, about 59.1% of the US population is fully vaccinated, and about 19.1% of those fully vaccinated have received a booster dose, according to data from the US Centers for Disease Control and Prevention.

The Omicron variant is another reason for people to get vaccinated and boosted against Covid-19, Dr. Francis Collins, director of the National Institutes of Health, said Monday.

“We still have, of course, in the US a serious surge of the Delta variant, we should be thinking about that,” he said when asked for his best advice regarding Omicron.

“Your best protection against Delta is to get vaccinated, and if you’ve already been vaccinated and six months have passed since you got Pfizer or Moderna, get your booster; two months since J&J, get your booster. …

“That was a reason already, but now add Omicron to the mix,” Collins told Jim Sciutto on CNN’s “Newsroom.” “And we do believe that this new variant, which will probably come to our shores, will also be something vaccines and boosters can help you with.”

Critical 2-week timeline

President Joe Biden on Monday called Omicron “a cause for concern, not a cause for panic.”

“We have the best vaccine in the world, the best medicines, best scientists, and we’re learning more every single day, and we’ll fight this variant with scientific and knowledgeable actions and speed, not chaos and confusion,” he said.

Biden on Sunday discussed the pandemic’s latest variant with Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases, and other members of his Covid response team.

“Dr. Fauci informed the President that while it will take approximately two more weeks to have more definitive information on the transmissibility, severity, and other characteristics of the variant, he continues to believe that existing vaccines are likely to provide a degree of protection against severe cases of Covid,” a readout of their meeting said.

As for immediate recommendations, the White House said the Covid team is recommending boosters for all eligible vaccinated adults.

“This is a clarion call as far as I’m concerned of saying let’s put aside all of these differences that we have, and say, if you’re not vaccinated, get vaccinated. If you’re fully vaccinated, get boosted,” Fauci told NBC News on Sunday.

If tests show antibodies from a person who has been vaccinated can neutralize the Omicron variant of the virus, then “we’re in pretty good shape,” Fauci explained.

“If it looks like even at a high (level) of antibody it doesn’t, then what you’ve got to do is you’ve got to change and modify what the vaccine is going to be, which you can do pretty easily,” Fauci said.

Moderna expects to know in a couple of weeks whether the new Omicron variant impacts the efficacy of its vaccine, its chief medical officer said Sunday.

If the company finds it needs to pivot and produce a new vaccine, Moderna is working on several approaches, including one that would be specific to the new variant, Dr. Paul Burton told CNN’s “Newsroom.”

“Our platform, we can move very fast. We think within weeks to maybe two to three months we would be able to have an Omicron-specific vaccine booster available for testing, and then for administration,” he said. “This is going to go at the fastest possible speed, but we have to do careful science now. We don’t want to misstep.”

BioNTech, the German company that partnered with Pfizer to make a Covid-19 vaccine, is also investigating Omicron’s impact on their vaccine, with data expected in the coming weeks.

Johnson & Johnson said it’s also testing the effectiveness of its vaccine against Omicron.

It’s too early to tell what the effect of the Omicron variant will be on protection from vaccines and previous infection, but there is reason to believe Pfizer’s antiviral pill could still work, said Collins of the National Institutes of Health.

There are two ways to figure this out: laboratory experiments and seeing what happens in the “real world,” he said.

“So, in South Africa, where some people are vaccinated and now that the virus is finding its way into other countries, can we start to see what the effectiveness is of the vaccine in preventing illness and particularly severe illness?” Collins said. “That will also take us a week or two to begin to see.”

US travel restrictions go into effect

Since the variant was first identified, it has also been found in Botswana, Belgium, Canada, Australia, the Netherlands, Denmark, the United Kingdom, Portugal, Germany, Israel, Italy, the Czech Republic and Hong Kong.

While the Biden administration believes the variant will likely show up the US, it instituted travel restrictions to buy time while health experts work to learn more about Omicron’s potential impact.

But on Sunday, the US Travel Association urged the Biden administration to reconsider the restrictions.

“Covid variants are of concern, but closed borders have not prevented their presence in the United States while vaccinations have proven incredibly durable. That is why America’s travel industry is a vocal proponent of everyone getting a vaccine,” the association said in a statement. “With a vaccine and testing requirement in place to enter the US we continue to believe that assessing an individual’s risk and health status is the best way to welcome qualified global travelers into the United States.”

Passengers fly Sunday from Johannesburg to Newark, New Jersey. - CNN

Meantime, passengers arriving Sunday morning at Newark International Airport on a direct flight from Johannesburg described the impact of global travel restrictions.

Kyle Bogert, of Hoboken, New Jersey, told CNN the rest of his family was still stranded in South Africa because their connecting flight through Dubai was canceled as they were on the way to the airport.

“On the news, you hear about all these variants popping up in different locations and you hear about airports getting shut down … it’s kind of in the back of your mind until you’re there and you’re stuck there, or your family is stuck there,” he said.

Passengers on Bogert’s flight were advised to get tested for Covid-19 “within three to five days,” he said, noting his exit from his flight was otherwise “normal.”

CNN’s Nikki Carvajal, John Bonifield, Michael Nedelman, Frederik Pleitgen, Naomi Thomas, Pete Muntean and Sarah Fortinsky contributed to this report.

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