College Football Odds Week 13: Over/Under and Picks Against the Spread for Top 25

College football's Week 13 slate is defined by rivalry games and big-time matchups that have the potential to shape the four-team College Football Playoff field.

Teams are running out of time to impress the CFP committee. With just two more weeks of action before conference champions are crowned and the bowl picture is solidified, the race is tightening.

A collision between two of the top four teams in Ohio State and Michigan is guaranteed to shake up the committee's rankings. Meanwhile, the one-loss USC Trojans get an opportunity to prove themselves against a ranked Notre Dame team.

For those who enjoy having some skin in the game, it's going to be a glorious weekend of college football.

The schedule is jam-packed with important matchups and interesting lines. Here's a look at the complete schedule with picks for each and a closer look at some of the bigger games on tap.

Caleb Williams could lead USC to the playoffs with a win over Notre Dame and some help.
Caleb Williams could lead USC to the playoffs with a win over Notre Dame and some help.

Thursday, Nov. 24

Mississippi State at No. 20 Ole Miss (-2), (61, over) 7 p.m. ET, ESPN

Friday, Nov. 25

No. 19 Tulane at No. 21 Cincinnati (-1), (46, over) noon ET, ABC

Baylor at No. 24 Texas (-9), (56, under) noon ET, ESPN

NC State at No. 18 North Carolina (-6.5), (56, over) 3:30 p.m. ET, ABC

No. 17 UCLA (-10) at California, (61, under) 4:30 p.m. ET, Fox

Florida at No. 16 Florida State (-9.5), (58, under) 7:30 p.m. ET, ABC

Saturday, Nov. 26

Georgia Tech at No. 1 Georgia (-35), (48.5, over) noon ET, ESPN

No. 3 Michigan at No. 2 Ohio State (-7.5), (56.5, over) noon ET, Fox

South Carolina at No. 7 Clemson (-14.5), (51.5, over) noon ET, ABC

No. 23 Coastal Carolina at James Madison (-14.5), (53.5, under) noon ET, ESPNU

Auburn at No. 8 Alabama (-22), (50, under) 3:30 p.m. ET, CBS

No. 10 Oregon (-3) at No. 22 Oregon State, (58.5, over) 3:30 p.m. ET, ABC

Iowa State at No. 4 TCU (-10), (47.5, under) 4 p.m. ET, Fox

Michigan State at No. 11 Penn State (-19), (53, under) 4 p.m. ET, FS1

No. 14 Utah (-30) at Colorado, (52, over) 4 p.m. ET, Pac-12 Network

No. 6 LSU (-10) at Texas A&M, (47.5, under) 7 p.m. ET, ESPN

No. 25 UCF (-19.5) at South Florida, (68, under) 7 p.m. ET, ESPN2

No. 13 Notre Dame at No. 5 USC (-5.5), (64.5, under) 7:30 p.m. ET, ABC

No. 9 Tennessee (-14) at Vanderbilt, (64.5, under) 7:30 p.m. ET, SEC Network

Kansas at No. 15 Kansas State (-11.5), (62.5, over) 8 p.m. ET, Fox

No. 12 Washington (-2) at Washington State, (60, over) 10:30 p.m. ET, ESPN

Predictions against the spread in bold. Odds via DraftKings Sportsbook.

C.J. Stroud had a lot of success against Michigan's defense last year.
C.J. Stroud had a lot of success against Michigan's defense last year.

The 2022 edition of The Game between Ohio State and Michigan is undoubtedly the game of the week. The Buckeyes are 7.5-point favorites, but they were also favored going into the game last season when Michigan finally snapped an eight-game losing streak to their rival.

There are a lot of similarities in this year's matchup.

The Buckeyes once again have a high-octane offense with one of the best passing attacks in the country. C.J. Stroud will attempt to put the finishing touches on a Heisman Trophy campaign.

With one of the best receiving groups in the country. Jaxon Smith-Njigba has been out of the lineup with a hamstring injury, but Emeka Egbuka and Marvin Harrison Jr. are still a devastating one-two punch.

Even in last year's matchup, Michigan struggled to contain Ohio State's explosive passing attack. Stroud had 394 yards and two touchdowns with no interceptions against the Wolverines last year.

The problem was the running game. Michigan had 297 yards and six touchdowns on the ground, led by Hassan Haskins, who had 169 yards and five touchdowns.

Blake Corum is the man to take on that role this season. He has 1,487 yards on the ground and 18 touchdowns this season, but he went down with a knee injury against Illinois last week. It's unclear what kind of condition he will be in against Ohio State.

That doesn't bode well, and Ohio State has had a year to fix the issues with the run defense and allow their offense to shine in the rivalry game.

Lincoln Riley has the USC Trojans on the brink of the playoff.
Lincoln Riley has the USC Trojans on the brink of the playoff.

Lincoln Riley and the USC Trojans have something to prove to the College Football Playoff committee this weekend.

In the latest rankings, the Trojans came in at No. 6. The fact they aren't ahead of any of the current top four makes sense. They have a one-point loss to Utah on their resume while the top four have undefeated records.

However, the fact they were slotted behind a two-loss LSU team at No. 5 is a bit of disrespect.

They'll have a chance to rectify that in a big night game against the Notre Dame Fighting Irish. The committee has shown they respect what Marcus Freeman's side can do, ranking them at No. 15.

Heisman hopeful Caleb Williams has the Trojans offense humming, but Notre Dame has the kind of defense that will test him. They are ranked 20th in the country in yards allowed per attempt (6.3) and give up 186.8 yards per contest.

Still, it's been a long time since the Irish have seen a passing attack like the one they will see Saturday night. They lost to Ohio State in 21-10 in September, but since then the likes of D.J. Uiagalelei and Carlos Del Rio-Wilson are the best quarterbacks they have seen.

The defense is good and will likely give USC more trouble than they are used to, but the recent play of Williams and the added motivation of making a push to the playoff is enough to make them the pick to cover the 5.5-point spread here.

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