Christina Applegate made a powerful statement with 'FU MS' manicure in first public appearance since multiple sclerosis diagnosis

• Christina Applegate showed off her "FU MS" manicure at the Hollywood Walk of Fame on Monday.

• The actress was honored with a star in her first appearance since being diagnosed with MS.

• The "Dead to Me" actress announced she had been diagnosed with the disease in August 2021.

Christina Applegate made a powerful statement about her MS diagnosis during her star unveiling ceremony at the Hollywood Walk of Fame on Monday.

The "Dead to Me" actress, 50, held her hands up for photos at the event, showing off a manicure that read "FU MS."

Applegate announced via Twitter in August 2021 that she had been diagnosed with multiple sclerosis, which can be defined as an "unpredictable disease of the central nervous system," according to the National Institute of Neurological Disorders and Stroke.

The disease disrupts communication between the brain and other parts of the body, and can cause symptoms such as blurred or double vision, muscle weakness, and speech impediments, the organization states on its website.

Applegate was honored with a Hollywood star at the event, which marked her first public outing since announcing her diagnosis, Variety reports.

The actress' manicurist, Vanessa Sanchez McCullough, wrote on Instagram Stories that she used Green Flash LED, a gel-replacement polish, in the shades Hollyhock and Snow by Manucurist Paris.

"Christina told me that she wanted to make a literal statement with her nails and wanted the letters FU MS on her nails," Sanchez told PopSugar. "We chose to do so in white, so it stood out on top of the moody, rich red color. We were both thrilled with the way they turned out."

Applegate also used the nail polish on her toenails, which was visible as she attended the ceremony barefoot.

"Barefoot. For some with MS the feeling of shoes may hurt or make us feel off balance. So today I was me. Barefoot," the actress wrote on Twitter, alongside a photo of her standing on her Hollywood star.

Applegate's hair stylist, Adir Abergel, shared a close-up image of Applegate's nails on Instagram.

"Today I got to celebrate you strength, your journey, your contributions to the arts and to building a community that loves you," Abergel wrote in the caption.

"Watching you receive your star on Hollywood Walk of Fame was both emotional and powerful," he added.

The caption continued: "Even after being diagnosed with MS you show up for yourself and the people that love you. I love that you got your nails done with a clear message to Multiple Sclerosis. F*** YOU MS. #FUMS."

Representatives for Christina Applegate, Vanessa Sanchez McCullough, Adir Abergel, and the Hollywood Walk of Fame did not immediately respond to Insider's request for comment.

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